# Group analyses with Lead-DBS

{% hint style="info" %}
Lead group is best documented by [this paper](https://www.biorxiv.org/content/10.1101/2020.01.14.904615v1) and the accompanying walkthrough tutorial found on [OSF](https://osf.io/kj456/).

An older resource are [these walkthrough slides](https://www.lead-dbs.org/docs/tutorials/group_analyses_horn.pdf)
{% endhint %}

Once the coregistration, normalization and reconstruction steps have been performed for a group of patients, you can load these in the group GUI, which you can start by entering

`lead group`

into the MATLAB command line.

From here, several options for visualization and analysis of clinical/multimodal data are available. The rest of this section explains how to [setup-analysis](https://netstim.gitbook.io/leaddbs/lead-group/setup-analysis "mention"), how to create [group-visualization](https://netstim.gitbook.io/leaddbs/lead-group/group-visualization "mention")s and how to [calculate-vta-and-stats](https://netstim.gitbook.io/leaddbs/lead-group/calculate-vta-and-stats "mention").

{% hint style="info" %}
Before starting, please make sure to check accuracy of both normalization and reconstruction for each patient you analyse.
{% endhint %}

*Lead-Group GUI*

<figure><img src="https://652347722-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FaEKrtfptpsNlKGfPk7Bs%2Fuploads%2F5vx6kKYt1ElO93l604Hz%2FScreen%20Shot%202023-08-07%20at%2015.54.28.png?alt=media&#x26;token=29d8df25-567d-446d-92cf-3bca6e443546" alt=""><figcaption></figcaption></figure>